Alexandros Papadopoulos , Dimitrios Iakovakis, Lisa Klingelhoefer, Sevasti Bostantjopoulou, K. Ray Chaudhuri, Konstantinos Kyritsis, Stelios Hadjidimitriou, Vasileios Charisis , Leontios J. Hadjileontiadis and Anastasios Delopoulos
"Unobtrusive detection of Parkinson’s disease from multi?modal and in?the?wild sensor data using deep learning techniques"
Scientific Reports, 2020 Dec
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, affecting more than 1% of the population above 60 years old with both motor and non-motor symptoms of escalating severity as it progresses. Since it cannot be cured, treatment options focus on the improvement of PD symptoms. In fact, evidence suggests that early PD intervention has the potential to slow down symptom progression and improve the general quality of life in the long term. However, the initial motor symptoms are usually very subtle and, as a result, patients seek medical assistance only when their condition has substantially deteriorated; thus, missing the opportunity for an improved clinical outcome. This situation highlights the need for accessible tools that can screen for early motor PD symptoms and alert individuals to act accordingly. Here we show that PD and its motor symptoms can unobtrusively be detected from the combination of accelerometer and touchscreen typing data that are passively captured during natural user-smartphone interaction. To this end, we introduce a deep learning framework that analyses such data to simultaneously predict tremor, fine-motor impairment and PD. In a validation dataset from 22 clinically-assessed subjects (8 Healthy Controls (HC)/14 PD patients with a total data contribution of 18.305 accelerometer and 2.922 typing sessions), the proposed approach achieved 0.86/0.93 sensitivity/specificity for the binary classification task of HC versus PD. Additional validation on data from 157 subjects (131 HC/26 PD with a total contribution of 76.528 accelerometer and 18.069 typing sessions) with self-reported health status (HC or PD), resulted in area under curve of 0.87, with sensitivity/specificity of 0.92/0.69 and 0.60/0.92 at the operating points of highest sensitivity or specificity, respectively. Our findings suggest that the proposed method can be used as a stepping stone towards the development of an accessible PD screening tool that will passively monitor the subject-smartphone interaction for signs of PD and which could be used to reduce the critical gap between disease onset and start of treatment.
Alexandros Papadopoulos, Konstantinos Kyritsis, Lisa Klingelhoefer, Sevasti Bostanjopoulou, K. Ray Chaudhuri and Anastasios Delopoulos
"Detecting Parkinsonian Tremor from IMU Data Collected In-The-Wild using Deep Multiple-Instance Learning"
IEEE Journal of Biomedical and Health Informatics, 2019 Dec
Parkinson's Disease (PD) is a slowly evolving neuro-logical disease that affects about 1% of the population above 60 years old, causing symptoms that are subtle at first, but whose intensity increases as the disease progresses. Automated detection of these symptoms could offer clues as to the early onset of the disease, thus improving the expected clinical outcomes of the patients via appropriately targeted interventions. This potential has led many researchers to develop methods that use widely available sensors to measure and quantify the presence of PD symptoms such as tremor, rigidity and braykinesia. However, most of these approaches operate under controlled settings, such as in lab or at home, thus limiting their applicability under free-living conditions. In this work, we present a method for automatically identifying tremorous episodes related to PD, based on IMU signals captured via a smartphone device. We propose a Multiple-Instance Learning approach, wherein a subject is represented as an unordered bag of accelerometer signal segments and a single, expert-provided, tremor annotation. Our method combines deep feature learning with a learnable pooling stage that is able to identify key instances within the subject bag, while still being trainable end-to-end. We validate our algo- rithm on a newly introduced dataset of 45 subjects, containing accelerometer signals collected entirely in-the-wild. The good classification performance obtained in the conducted experiments suggests that the proposed method can efficiently navigate the noisy environment of in-the-wild recordings.
A. Papadopoulos, K. Kyritsis, S. Bostanjopoulou, L. Klingelhoefer, R. K. Chaudhuri and A. Delopoulos
2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019 Jul
Parkinson’s Disease (PD) is a neurodegenerative disorder that manifests through slowly progressing symptoms, such as tremor, voice degradation and bradykinesia. Automated detection of such symptoms has recently received much attention by the research community, owing to the clinical benefits associated with the early diagnosis of the disease. Unfortunately, most of the approaches proposed so far, operate under a strictly laboratory setting, thus limiting their potential applicability in real world conditions. In this work, we present a method for automatically detecting tremorous episodes related to PD, based on acceleration signals. We propose to address the problem at hand, as a case of Multiple-Instance Learning, wherein a subject is represented as an unordered bag of signal segments and a single, expert-provided, ground-truth. We employ a deep learning approach that combines feature learning and a learnable pooling stage and is trainable end-to-end. Results on a newly introduced dataset of accelerometer signals collected in-the-wild confirm the validity of the proposed approach.
Alexandros Papadopoulos, Konstantinos Kyritsis, Ioannis Sarafis and Anastasios Delopoulos
40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), IEEE, Honolulu, HI, USA, 2018 Oct
Automated monitoring and analysis of eating behaviour patterns, i.e., “how one eats”, has recently received much attention by the research community, owing to the association of eating patterns with health-related problems and especially obesity and its comorbidities. In this work, we introduce an improved method for meal micro-structure analysis. Stepping on a previous methodology of ours that combines feature extraction, SVM micro-movement classification and LSTM sequence modelling, we propose a method to adapt a pretrained IMU-based food intake cycle detection model to a new subject, with the purpose of improving model performance for that subject. We split model training into two stages. First, the model is trained using standard supervised learning techniques. Then, an adaptation step is performed, where the model is fine-tuned on unlabeled samples of the target subject via semisupervised learning. Evaluation is performed on a publicly available dataset that was originally created and used in  and has been extended here to demonstrate the effect of the semisupervised approach, where the proposed method improves over the baseline method.